Induced pluripotent stem cells (usually abbreviated as iPS cells, for its acronym in English: "induced Pluripotent Stem") are a type of stem cells with pluripotent characteristics (capable of generating most tissues).
Now, a library of well-characterized human-induced pluripotent stem cell (hiPSC) lines from clinically healthy humans has been developed by Mount Sinai researchers. This library of gender-balanced, racially, and ethnically diverse hiPSC lines was generated from 40 clinically healthy men and women ages 22-61.
Development of future drugs
This library can serve as a valuable resource for normal controls for in vitro human development, genotype-phenotype association studies, many diseases, and drug response evaluations.
Therefore, the research is an important technological development of precise cell-based models that can be used for drug discovery and the prediction of drug adverse effects .
While the study that generates the cell lines does not have a direct impact on patient care or treatment, the library can support rigorous disease modeling, accurate assessment of patient responses to medications, and future studies of genotype-phenotype association.