Metabolites are substances that are made or used when the body breaks down food, drugs, or chemicals during metabolism. Its alteration could be behind the migraines .
Three levels of metabolites
The relationships observed between genetic factors influencing blood metabolite levels and the genetic risk of migraine suggest an alteration of metabolites in people with migraine. The team identified causal genetic links to three levels of metabolites in the blood that increase migraine risk :
- Lower levels of DHA, an omega-3 known to reduce inflammation. People with migraines had higher levels of shorter fatty acids except for docosahexaenoic acid (DHA), a very long-chain omega-3 that protects against migraine headaches.
- Higher levels of LPE (20: 4), a chemical that blocks an anti-inflammatory molecule.
- Lower levels of a third metabolite, currently uncharacterized, called X-11315.
These genetic links could now be the target of future research and clinical trials to develop and test compounds that influenced metabolite levels and prevented migraine headaches.